For research use only. Not for therapeutic Use.
Moricizine（Cat No.:I003137）is an antiarrhythmic medication used to treat certain types of abnormal heart rhythms, particularly ventricular arrhythmias. It works by stabilizing the electrical activity of the heart, inhibiting sodium channels, and prolonging the refractory period of cardiac cells, thus reducing the risk of irregular heartbeats. Moricizine is classified as a Class 1c antiarrhythmic, but due to its potential for serious side effects, including proarrhythmia and cardiac toxicity, it is typically used when other treatments are ineffective. It has been largely replaced by newer antiarrhythmic drugs in clinical practice, though it may still be used in specific cases.
| Catalog Number | I003137 |
| CAS Number | 31883-05-3 |
| Molecular Formula | C22H25N3O4S |
| Purity | ≥95% |
| Target | Sodium Channel |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate |
| InChI | InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27) |
| InChIKey | FUBVWMNBEHXPSU-UHFFFAOYSA-N |
| SMILES | CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4 |
| Reference | </br>1:[Moricizine in treatment of one case with tachycardia-induced cardiomyopathy]. Ding WH, Han L, Jin M, Wang XF, Zheng K, Guo BJ.Zhonghua Er Ke Za Zhi. 2003 Oct;41(10):785. Chinese. No abstract available. PMID: 14731369 </br>2:Moricizine induced increase in pacing threshold. Girod JP, Marrouche N, Chen MS, Natale A.Pacing Clin Electrophysiol. 2003 Jan;26(1 Pt 1):110-1. PMID: 12685150 </br>3:Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block. Ahmmed GU, Hisatome I, Kurata Y, Makita N, Tanaka Y, Tanaka H, Okamura T, Sonoyama K, Furuse Y, Kato M, Yamamoto Y, Ogura K, Shimoyama M, Miake J, Sasaki N, Ogino K, Igawa O, Yoshida A, Shigemasa C.Vascul Pharmacol. 2002 Mar;38(3):131-41. PMID: 12402511 </br>4:Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A. Konishi H, Morita K, Minouchi T, Yamaji A.Pharmacology. 2002 Dec;66(4):190-8. PMID: 12393941 </br>5:Efficacy and safety of moricizine in the maintenance of sinus rhythm in patients with recurrent atrial fibrillation. Geller JC, Geller M, Carlson MD, Waldo AL.Am J Cardiol. 2001 Jan 15;87(2):172-7. PMID: 11152834 </br>6:Human moricizine metabolism. II. Quantification and pharmacokinetics of plasma and urinary metabolites. Pieniaszek HJ Jr, Davidson AF, Chaney JE, Shum L, Robinson CA, Mayersohn M.Xenobiotica. 1999 Sep;29(9):945-55. PMID: 10548454 </br>7:Moricizine bioavailability via simultaneous, dual, stable isotope administration: bioequivalence implications. Pieniaszek HJ Jr, Mayersohn M, Adams MP, Reinhart RJ, Barrett JS.J Clin Pharmacol. 1999 Aug;39(8):817-25. PMID: 10434234 </br>8:Human moricizine metabolism. I. Isolation and identification of metabolites in human urine. Richards LE, Pieniaszek HJ Jr, Shatzmiller S, Page GO, Blom KF, Read JM, Davidson AF, Confalone PN.Xenobiotica. 1997 Feb;27(2):217-29. Erratum in: Xenobiotica 1999 Sep;29(9):969. PMID: 9058534 </br>9:Pharmacokinetic interactions of moricizine and diltiazem in healthy volunteers. Shum L, Pieniaszek HJ Jr, Robinson CA, Davidson AF, Widner PJ, Benedek IH, Flamenbaum W.J Clin Pharmacol. 1996 Dec;36(12):1161-8. PMID: 9013374 </br>10:Experience with moricizine HCl in children with supraventricular tachycardia. Mehta AV, Subrahmanyam AB, Long JB, Kanter RJ.Int J Cardiol. 1996 Nov 15;57(1):31-5. PMID: 8960940 |
