For research use only. Not for therapeutic Use.
Morinidazole（Cat No.:I005505）is a nitroimidazole antimicrobial agent primarily used for the treatment of anaerobic infections. It functions by disrupting the DNA structure of bacteria, preventing replication and leading to cell death. Morinidazole is effective against a range of Gram-positive and Gram-negative anaerobic organisms and is commonly used in gastrointestinal and gynecological infections. It demonstrates a lower incidence of side effects compared to other nitroimidazole derivatives, making it a preferred option in certain clinical settings. With its targeted action, Morinidazole is crucial in combating infections resistant to conventional antibiotics.
| Catalog Number | I005505 |
| CAS Number | 92478-27-8 |
| Molecular Formula | C11H18N4O4 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | No data available |
| Storage | Store at -20C |
| IUPAC Name | 1-(2-methyl-5-nitroimidazol-1-yl)-3-morpholin-4-ylpropan-2-ol |
| InChI | InChI=1S/C11H18N4O4/c1-9-12-6-11(15(17)18)14(9)8-10(16)7-13-2-4-19-5-3-13/h6,10,16H,2-5,7-8H2,1H3 |
| InChIKey | GAZGHCHCYRSPIV-UHFFFAOYSA-N |
| SMILES | CC1=NC=C(N1CC(CN2CCOCC2)O)[N+](=O)[O-] |
| Reference | </br>1:Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins. Kong F, Pang X, Zhong K, Guo Z, Li X, Zhong D, Chen X.Drug Metab Dispos. 2017 Jun;45(6):593-603. doi: 10.1124/dmd.116.074492. Epub 2017 Mar 17. PMID: 28314825 </br>2:Efficacy and safety of morinidazole in pelvic inflammatory disease: results of a multicenter, double-blind, randomized trial. Cao C, Luo A, Wu P, Weng D, Zheng H, Wang S.Eur J Clin Microbiol Infect Dis. 2017 Mar 6. doi: 10.1007/s10096-017-2913-z. [Epub ahead of print] PMID: 28265816 </br>3:Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects. Pang X, Zhang Y, Gao R, Zhong K, Zhong D, Chen X.Antimicrob Agents Chemother. 2014 Oct;58(10):5987-93. doi: 10.1128/AAC.03382-14. Epub 2014 Jul 28. PMID: 25070100 Free PMC Article</br>4:A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific determination of morinidazole in human plasma. Zhong K, Gao Z, Li Q, Zhong D, Chen X.J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 15;961:49-55. doi: 10.1016/j.jchromb.2014.04.049. Epub 2014 May 2. PMID: 24858695 </br>5:Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites. Zhong K, Li X, Xie C, Zhang Y, Zhong D, Chen X.Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61. doi: 10.1128/AAC.02414-14. Epub 2014 May 12. PMID: 24820074 Free PMC Article</br>6:Pharmacokinetics of single-dose morinidazole in patients with severe renal impairment. Zhang H, Huang L, Huang YY, Yi B, Pei Q, Tan HY, Huang J, Liu JS, Yuan H, Yang GP.Int J Clin Pharmacol Ther. 2014 Feb;52(2):159-65. doi: 10.5414/CP202000. PMID: 24290410 </br>7:Comment on /Simultaneous quantification of metronidazole, tinidazole, ornidazole and morinidazole in human saliva/: Saliva or gingival crevicular fluid? Jiang Y, Wu X, Lingling E.J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 15;913-914:169-70. doi: 10.1016/j.jchromb.2012.11.022. Epub 2012 Dec 13. No abstract available. PMID: 23314355 </br>8:Simultaneous determination of morinidazole and its carbonylation metabolite in human plasma: application to a pharmacokinetic study involving renal insufficiency patients and healthy volunteers. Tan H, Yang G, Yu P, Huang Y, Pei Q, Yuan H, Huang Z, Xie F, Mu L.J Pharm Biomed Anal. 2013 Mar 25;76:75-80. doi: 10.1016/j.jpba.2012.11.037. Epub 2012 Dec 13. PMID: 23298909 </br>9:Simultaneous determination of morinidazole, its N-oxide, sulfate, and diastereoisomeric N(+)-glucuronides in human plasma by liquid chromatography-tandem mass spectrometry. Gao R, Zhong D, Liu K, Xia Y, Shi R, Li H, Chen X.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:52-8. doi: 10.1016/j.jchromb.2012.09.017. Epub 2012 Sep 25. PMID: 23122401 </br>10:Simultaneous quantification of metronidazole, tinidazole, ornidazole and morinidazole in human saliva. Wang Y, Zhang P, Jiang N, Gong X, Meng L, Wang D, Ou N, Zhang H.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:27-30. doi: 10.1016/j.jchromb.2012.04.032. Epub 2012 May 15. PMID: 22658465 |
