Morinidazole R enantiomer

• CAT Number: I005376
• CAS Number: 898230-59-6
• Molecular Formula: C11H18N4O4
• Molecular Weight: 270.29
• Purity: ≥95%
• Target: Bacterial
• Solubility: No data available
• Storage: Store at -20°C
• IUPAC Name: (2R)-1-(2-methyl-5-nitroimidazol-1-yl)-3-morpholin-4-ylpropan-2-ol
• InChI: InChI=1S/C11H18N4O4/c1-9-12-6-11(15(17)18)14(9)8-10(16)7-13-2-4-19-5-3-13/h6,10,16H,2-5,7-8H2,1H3/t10-/m1/s1
• InChIKey: GAZGHCHCYRSPIV-SNVBAGLBSA-N
• SMILES: CC1=NC=C(N1C[C@@H](CN2CCOCC2)O)[N+](=O)[O-]

Morinidazole R-enantiomer（Cat No.:I005376）is the optically active form of morinidazole, an antimicrobial agent in the nitroimidazole class, used to treat anaerobic bacterial and protozoal infections. This R-enantiomer exhibits distinct pharmacokinetic and pharmacodynamic properties that may enhance efficacy and reduce toxicity compared to its S-enantiomer or racemic mixture. Known for its role in treating infections like intra-abdominal infections and bacterial vaginosis, it works by disrupting DNA synthesis in anaerobic pathogens. This targeted approach minimizes adverse effects, making the R-enantiomer a focus in optimizing morinidazole-based therapies.

Reference

[1]. Zhong K, et al. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearanceof the conjugated metabolites. Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61.