Motexafin gadolinium

• CAT Number: I007581
• CAS Number: 246252-06-2
• Molecular Formula: C52H72GdN5O14
• Molecular Weight: 1148.42
• Purity: ≥95%
• Synonyms: PCI 0120; PCI-0120; PCI0120; API-GP 3; Gd texaphyrin; Gd-Texgadolinium; texaphyrin; Gd (III) Texaphryin. US brand name: Xcytrin. Abbreviation: GdTex.;Gadolinium, bis(acetato-kappaO)(9,10-diethyl-20,21-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-4,15-dim
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: 3-[4,5-diethyl-24-(3-hydroxypropyl)-16,17-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-10,23-dimethyl-13,20,25,26-tetraza-27-azanidapentacyclo[20.2.1.13,6.18,11.014,19]heptacosa-1(25),2,4,6,8(26),9,11,13,15,17,19,21,23-tridecaen-9-yl]propan-1-ol;gadolinium(3+);diacetate
• InChI: InChI=1S/C48H66N5O10.2C2H4O2.Gd/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;2*1-2(3)4;/h27-32,54-55H,7-
• InChIKey: LAUAZTXAMPOVHP-WRIGXHCHSA-L, VAZLWPAHMORDGR-WRIGXHCHSA-L
• SMILES: CCC1=C(C2=CC3=NC(=CN=C4C=C(C(=CC4=NC=C5C(=C(C(=N5)C=C1[N-]2)CCCO)C)OCCOCCOCCOC)OCCOCCOCCOC)C(=C3CCCO)C)CC.CC(=O)[O-].CC(=O)[O-].[Gd+3]

Motexafin gadolinium (CAT: I007581) is a tumor-targeting redox-active texaphyrin compound that selectively accumulates in cancer cells. It disrupts cellular redox processes by generating reactive oxygen species (ROS) and depleting reducing agents like NADPH and glutathione, leading to oxidative stress and apoptosis. MGd also enhances the sensitivity of cancer cells to radiation therapy and certain chemotherapeutic agents. Its gadolinium component provides imaging capabilities, making it a dual-purpose agent for both treatment and diagnostics. Motexafin gadolinium is widely studied in oncology research, particularly for treating cancers like glioblastoma and lung cancer, and for exploring redox-based therapeutic strategies.