mPEG2000-DSPE

• CAT Number: I032730
• CAS Number: 247925-28-6
• Molecular Formula: C45H87NNaO11P
• Molecular Weight: 872.15
• Purity: 98%
• Synonyms: mPEG2000-DSPE; 1,2-Distearoyl-ras-glycero-3-PE-N-Polyethyleneglycol-2000; 1,2-Distearoyl-ras-glycerol-3-Phosphatidylethanolamine-N-Polyethyleneglycol-2000; 1,2-Distearoyl-ras-glycerol-3-Phosphoethanolamine-N-Polyethyleneglycol-2000
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: sodium 2,3-bis(stearoyloxy)propyl (2-(((2-methoxyethoxy)carbonyl)amino)ethyl) phosphate
• InChI: InChI=1S/C45H88NO11P.Na/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-43(47)54-40-42(41-56-58(50,51)55-37-36-46-45(49)53-39-38-52-3)57-44(48)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2;/h42H,4-41H2,1-3H3,(H,46,49)(H,50,51);/q;+1/p-1
• InChIKey: SRLOHQKOADWDBV-UHFFFAOYSA-M
• SMILES: O=P([O-])(OCC(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)OCCNC(OCCOC)=O.[Na+]

mPEG2000-DSPE (Cat.No:I032730) is used in COVID 19 mRNA vaccines. It is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095). Formulations containing DSPE-MPEG(2000) have been used to prepare liposomes with long circulation time for the delivery of anticancer and antimalarial agents.. mPEG2000-DSPE has also been widely used as hydrophilic surface modifying agent for a variety types of hydrophobic nanoparticles, including recently reported lipid nanoparticle mRNA vaccines.

Reference

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