MPEP hydrochloride

• CAT Number: I002681
• CAS Number: 219911-35-0
• Molecular Formula: C14H12ClN
• Molecular Weight: 229.71
• Purity: ≥95%
• Synonyms: 2-methyl-6-(2-phenylethynyl)pyridine;hydrochloride
• Target: Neuronal Signaling
• Solubility: DMSO ≥30 mg/mL; Water <1 mg/mL
• Storage: Store at -20°C
• IC50: 36 nM
• InChI: InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
• InChIKey: PKDHDJBNEKXCBI-UHFFFAOYSA-N
• SMILES: CC1=NC(=CC=C1)C#CC2=CC=CC=C2.Cl

MPEP hydrochloride (Cat No.:I002681) is a selective antagonist of the metabotropic glutamate receptor 5 (mGluR5), a receptor involved in neurotransmission and linked to various neurological disorders. MPEP is commonly used in preclinical research to study the role of mGluR5 in conditions such as Parkinson’s disease, schizophrenia, anxiety, and drug addiction. By inhibiting mGluR5, MPEP can modulate glutamate signaling in the brain, which may help alleviate symptoms associated with these disorders. It is primarily used in research settings to explore potential therapeutic approaches targeting glutamatergic dysfunction.

Reference

[1]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/antidepressant drug. Neuropharmacology (2012), 62(5-6), 2034-2039.
[2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.
[3]. D/’Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. Neuropharmacology (2011), 61(8), 1399-1405.