MPH-220

• CAT Number: I042303
• CAS Number: 2649776-79-2
• Molecular Formula: C20H21N3O3S
• Molecular Weight: 383.46
• Purity: ≥95%
• Synonyms: (9S)-9-hydroxy-5-methyl-12-(4-morpholin-4-ylphenyl)-4-thia-2,12-diazatricyclo[7.3.0.03,7]dodeca-1,3(7),5-trien-8-one
• InChI: InChI=1S/C20H21N3O3S/c1-13-12-16-17(24)20(25)6-7-23(19(20)21-18(16)27-13)15-4-2-14(3-5-15)22-8-10-26-11-9-22/h2-5,12,25H,6-11H2,1H3/t20-/m1/s1
• InChIKey: KUIAFBSRBMWQQP-HXUWFJFHSA-N
• SMILES: CC1=CC2=C(S1)N=C3C(C2=O)(CCN3C4=CC=C(C=C4)N5CCOCC5)O

MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].
MPH-220 (0-50 µM) inhibits Actin-activated ATPase activity in human muscle myosin samples[1].
MPH-220 (25-30 mg/kg, i.p. or oral gavage) reduces skeletal muscle force without cardiovascular effects in anesthetized rats[1].
MPH-220 (15 mg/kg, oral administration) improves gait functions in rats with brain injury[1].

Reference

[1]. Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183(2):335-346.e13.
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