MPH-220

• CAT Number: I042303
• CAS Number: 2649776-79-2
• Molecular Formula: C20H21N3O3S
• Molecular Weight: 383.46
• Purity: ≥95%
• Synonyms: (9S)-9-hydroxy-5-methyl-12-(4-morpholin-4-ylphenyl)-4-thia-2,12-diazatricyclo[7.3.0.03,7]dodeca-1,3(7),5-trien-8-one
• InChI: InChI=1S/C20H21N3O3S/c1-13-12-16-17(24)20(25)6-7-23(19(20)21-18(16)27-13)15-4-2-14(3-5-15)22-8-10-26-11-9-22/h2-5,12,25H,6-11H2,1H3/t20-/m1/s1
• InChIKey: KUIAFBSRBMWQQP-HXUWFJFHSA-N
• SMILES: CC1=CC2=C(S1)N=C3[C@](C2=O)(CCN3C4=CC=C(C=C4)N5CCOCC5)O

MPH-220（Cat No.:I042303）is a potent, selective inhibitor of the protein kinase C (PKC) family, specifically targeting PKCθ, which is implicated in T-cell activation and immune response regulation. By inhibiting PKCθ, MPH-220 aims to modulate immune responses, particularly in autoimmune diseases and certain types of cancer. It shows potential in reducing T-cell-mediated inflammation and in preventing tumor growth by blocking immune evasion mechanisms. Preclinical studies suggest MPH-220 could be beneficial in diseases like rheumatoid arthritis and in enhancing anti-tumor immunity, offering a promising approach to immunotherapy and inflammation management.