For research use only. Not for therapeutic Use.
MPP hydrochloride (Cat No.:I043635) is a neurotoxic compound widely used in research to model Parkinson’s disease. It is the active metabolite of MPTP, a protoxin that crosses the blood-brain barrier and is converted into MPP⁺ by monoamine oxidase-B in glial cells. MPP⁺ selectively enters dopaminergic neurons via the dopamine transporter and accumulates in mitochondria, where it disrupts oxidative phosphorylation, leading to energy failure and cell death. This compound is a valuable tool for studying dopaminergic neurodegeneration, mitochondrial dysfunction, and potential neuroprotective strategies in Parkinson’s disease research.
| CAS Number | 2863676-89-3 |
| Synonyms | 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazol-3-yl]phenol;hydrochloride |
| Molecular Formula | C29H32ClN3O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazol-3-yl]phenol;hydrochloride |
| InChI | InChI=1S/C29H31N3O3.ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;/h5-16,33-34H,2-4,17-20H2,1H3;1H |
| InChIKey | NUFZYMONJXOTFN-UHFFFAOYSA-N |
| SMILES | CC1=C(N(N=C1C2=CC=C(C=C2)O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
