For research use only. Not for therapeutic Use.
Mpro inhibitor N3 is a potent SARS-CoV-2 MPro inhibitor with an EC50 value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59[1][2][3].
Mpro inhibitor N3 (0-100 µM) shows antiviral activities with an EC50 value of 16.77 µM for SARS-CoV-2[1].
Mpro inhibitor N3 (0-50 µM; 14 h) inhibits the viral growth with the IC50 values of 4, 8.8, 2.7 µM for HCoV-229E, FIPV, IBV and MHV-A59, respectively[2].
Mpro inhibitor N3 (0-0.64 µM; 3, 6 h) shows antiviral activity against IBV in chicken , embryos[3].
| Catalog Number | I032745 |
| CAS Number | 884650-98-0 |
| Synonyms | benzyl (E,4S)-4-[[(2S)-4-methyl-2-[[(2S)-3-methyl-2-[[(2S)-2-[(5-methyl-1,2-oxazole-3-carbonyl)amino]propanoyl]amino]butanoyl]amino]pentanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate |
| Molecular Formula | C35H48N6O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C35H48N6O8/c1-20(2)16-27(39-35(47)30(21(3)4)40-31(43)23(6)37-34(46)28-17-22(5)49-41-28)33(45)38-26(18-25-14-15-36-32(25)44)12-13-29(42)48-19-24-10-8-7-9-11-24/h7-13,17,20-21,23,25-27,30H,14-16,18-19H2,1-6H3,(H,36,44)(H,37,46)(H,38,45)(H,39,47)(H,40,43)/b13-12+/t23-,25-,26+,27-,30-/m0/s1 |
| InChIKey | IDBWWEGDLCFCTD-VNEMRZQUSA-N |
| SMILES | CC1=CC(=NO1)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC2CCNC2=O)C=CC(=O)OCC3=CC=CC=C3 |
| Reference | [1]. Jin Z, et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 Jun;582(7811):289-293. [2]. Yang H, et al. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol. 2005 Oct;3(10):e324. [3]. Xue X, et al. Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J Virol. 2008 Mar;82(5):2515-27. |
