For research use only. Not for therapeutic Use.
MPT0E028（Cat No.:I008145）is a novel small-molecule inhibitor with potent anticancer properties, targeting tubulin polymerization. By disrupting microtubule dynamics, it effectively inhibits cancer cell proliferation and induces apoptosis. MPT0E028 has shown promising efficacy in preclinical studies for various cancer types, including multidrug-resistant cancers, making it a potential candidate for overcoming resistance mechanisms. This compound also exhibits anti-angiogenic properties, further contributing to its potential as a therapeutic agent. MPT0E028 is widely used in pharmaceutical research to investigate novel strategies for cancer treatment and the development of targeted therapies.
| Catalog Number | I008145 |
| CAS Number | 1338320-94-7 |
| Synonyms | MPT-0E028; MPT0E028; MPT 0E028;(E)-N-hydroxy-3-(1-(phenylsulfonyl)indolin-5-yl)acrylamide |
| Molecular Formula | C17H16N2O4S |
| Purity | ≥95% |
| Target | HDAC inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (E)-3-[1-(benzenesulfonyl)-2,3-dihydroindol-5-yl]-N-hydroxyprop-2-enamide |
| InChI | InChI=1S/C17H16N2O4S/c20-17(18-21)9-7-13-6-8-16-14(12-13)10-11-19(16)24(22,23)15-4-2-1-3-5-15/h1-9,12,21H,10-11H2,(H,18,20)/b9-7+ |
| InChIKey | MGTIFSBCGGAZDB-VQHVLOKHSA-N |
| SMILES | C1CN(C2=C1C=C(C=C2)/C=C/C(=O)NO)S(=O)(=O)C3=CC=CC=C3 |
| Reference | </br>1:Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Huang HL, Peng CY, Lai MJ, Chen CH, Lee HY, Wang JC, Liou JP, Pan SL, Teng CM.Oncotarget. 2015 Mar 10;6(7):4976-91. PMID: 25669976 Free PMC Article</br>2:Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo. Chen CH, Chen MC, Wang JC, Tsai AC, Chen CS, Liou JP, Pan SL, Teng CM.Clin Cancer Res. 2014 Mar 1;20(5):1274-87. doi: 10.1158/1078-0432.CCR-12-3909. Epub 2014 Feb 11. PMID: 24520095 Free PMC Article</br>3:The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells. Chen MC, Chen CH, Wang JC, Tsai AC, Liou JP, Pan SL, Teng CM.Cell Death Dis. 2013 Sep 19;4:e810. doi: 10.1038/cddis.2013.330. PMID: 24052078 Free PMC Article</br>4:Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo. Huang HL, Lee HY, Tsai AC, Peng CY, Lai MJ, Wang JC, Pan SL, Teng CM, Liou JP.PLoS One. 2012;7(8):e43645. doi: 10.1371/journal.pone.0043645. Epub 2012 Aug 22. Erratum in: PLoS One. 2012;7(9). doi: 10.1371/annotation/ab4fff87-6a32-4718-aa4c-91658f164b8d. Huang, Han-Lin [corrected to Huang, Han-Li]. PMID: 22928010 Free PMC Article |
