MPTP hydrochloride

• CAT Number: I002755
• CAS Number: 23007-85-4
• Molecular Formula: C12H15N • HCl
• Molecular Weight: 209.71
• Purity: ≥95%
• Synonyms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;NSC 139654
• Solubility: DMSO: ≥ 12 mg/mL
• Storage: Store at 4°C
• IC50: 53uM（inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice).
• IUPAC Name: 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine;hydrochloride
• InChI: InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
• InChIKey: KOWJANGMTAZWDT-UHFFFAOYSA-N
• SMILES: CN1CCC(=CC1)C2=CC=CC=C2.Cl

MPTP hydrochloride (Cat.No:I002755) is a neurotoxin that is commonly used in research to study Parkinson’s disease. It selectively damages dopamine-producing neurons in the brain, leading to motor dysfunction similar to the symptoms of Parkinson’s. Due to its ability to induce Parkinsonism, MPTP is valuable for studying the disease’s pathophysiology and developing new therapeutic approaches.

Reference

[1]. Desole M S, Esposito G, Fresu L. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat. Source:Pharmacol.Biochem.Behav., 1996, 54, No. 2, 377-83.
[2]. Hsu K S, Lin Shiau S Y. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.
[3]. Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12.