For research use only. Not for therapeutic Use.
MRE-269 (Cat No.: I003650) is a potent agonist that specifically targets prostaglandin I2 receptors. Notably, its binding affinity to human prostaglandin I2 receptors is exceptionally high, being approximately 130 times greater than its affinity for other human prostaglandin receptors. This selectivity for prostaglandin I2 receptors makes MRE-269 a valuable tool for researchers studying the effects and mechanisms of prostaglandin I2 receptor activation, as well as its potential applications in various biological processes. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I003650 |
| CAS Number | 475085-57-5 |
| Synonyms | [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid |
| Molecular Formula | C25H29N3O3 |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Solubility | DMSO |
| Storage | -20°C |
| IUPAC Name | 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-ylamino]butoxy]acetic acid |
| InChI | InChI=1S/C25H29N3O3/c1-19(2)28(15-9-10-16-31-18-23(29)30)22-17-26-24(20-11-5-3-6-12-20)25(27-22)21-13-7-4-8-14-21/h3-8,11-14,17,19H,9-10,15-16,18H2,1-2H3,(H,29,30) |
| InChIKey | OJQMKCBWYCWFPU-UHFFFAOYSA-N |
| SMILES | CC(C)N(CCCCOCC(=O)O)C1=CN=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3 |
| Reference | </br>1:A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries. Fuchikami C, Murakami K, Tajima K, Homan J, Kosugi K, Kuramoto K, Oka M, Kuwano K.Eur J Pharmacol. 2017 Jan 15;795:75-83. doi: 10.1016/j.ejphar.2016.11.057. Epub 2016 Dec 3. PMID: 27919660 </br>2:Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins. Orie NN, Ledwozyw A, Williams DJ, Whittle BJ, Clapp LH.Prostaglandins Other Lipid Mediat. 2013 Oct;106:1-7. doi: 10.1016/j.prostaglandins.2013.07.003. Epub 2013 Jul 18. PMID: 23872196 </br>3:A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), on rat pulmonary artery. Kuwano K, Hashino A, Noda K, Kosugi K, Kuwabara K.J Pharmacol Exp Ther. 2008 Sep;326(3):691-9. doi: 10.1124/jpet.108.138305. Epub 2008 Jun 13. PMID: 18552131 Free Article |
