For research use only. Not for therapeutic Use.
MreB Perturbing Compound A22 hydrochloride is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. MreB Perturbing Compound A22 hydrochloride blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC=3.1 µg/ml).
| Catalog Number | R065111 |
| CAS Number | 22816-60-0 |
| Synonyms | (3,4-dichlorophenyl)methyl carbamimidothioate;hydrochloride |
| Molecular Formula | C8H9Cl3N2S |
| Purity | ≥95% |
| InChI | InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H |
| InChIKey | VBJNMXMOMSWRDV-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1CSC(=N)N)Cl)Cl.Cl |
| Reference | [1]. Zemer Gitai, et al. MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell. 2005 Feb 11;120(3):329-41. [2]. Noritaka Iwai, et al. Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. Biosci Biotechnol Biochem. 2002 Dec;66(12):2658-62. |
