MrgprX2 antagonist-4

• CAT Number: I045162
• CAS Number: 2641398-04-9
• Molecular Formula: C16H19N3O
• Molecular Weight: 269.34
• Purity: ≥95%
• Synonyms: 3-ethyl-7-methyl-2-propan-2-yl-1H-pyrimido[1,2-a]benzimidazol-4-one
• InChI: InChI=1S/C16H19N3O/c1-5-11-14(9(2)3)18-16-17-12-7-6-10(4)8-13(12)19(16)15(11)20/h6-9H,5H2,1-4H3,(H,17,18)
• InChIKey: GEBQJASGYKVDHG-UHFFFAOYSA-N
• SMILES: CCC1=C(NC2=NC3=C(N2C1=O)C=C(C=C3)C)C(C)C

MrgprX2 antagonist-4 is an MrgprX2 antagonist extracted from patent US20210128561A1, compound B-51 E117. MrgprX2 antagonist-4 can be used for the research of inflammatory disorders of the skin[1].
MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions[2].

Reference

[1]. Müller C, et, al. MRGX Receptor Antagonists. US20210128561A1.

[2]. Porebski G, et, al. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions. Front Immunol. 2018 Dec 20;9:3027.
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