MrgprX2 antagonist-8（Cat No.:I043560）is a selective small-molecule inhibitor targeting the Mas-related G-protein coupled receptor X2 (MrgprX2), which is primarily expressed on mast cells and plays a key role in non-IgE-mediated allergic reactions and pseudo-allergic responses. By blocking MrgprX2 activation, this antagonist prevents mast cell degranulation and the release of pro-inflammatory mediators such as histamine. MrgprX2 antagonist-8 is a promising candidate for treating conditions like chronic urticaria, asthma, and drug-induced hypersensitivity. It also serves as a valuable research tool for investigating mast cell biology and the mechanisms underlying allergic and inflammatory diseases.