For research use only. Not for therapeutic Use.
MRGPRX4 modulator-2（Cat No.:I043532）is a selective small-molecule compound that targets Mas-related G-protein coupled receptor X4 (MRGPRX4), a receptor predominantly expressed in sensory neurons and associated with itch perception and cholestatic pruritus. By modulating MRGPRX4 activity, this compound offers a novel approach to managing chronic itch conditions, especially those linked to liver disease and opioid-induced pruritus. MRGPRX4 modulator-2 serves as a valuable pharmacological tool for investigating sensory neuron signaling and the molecular mechanisms of itch. It holds therapeutic potential for developing targeted treatments for pruritus and related sensory disorders with fewer side effects.
| CAS Number | 2492595-24-9 |
| Synonyms | 3-[[2-chloro-4-(trifluoromethyl)phenoxy]methyl]-2-fluorobenzoic acid |
| Molecular Formula | C15H9ClF4O3 |
| Purity | ≥95% |
| IUPAC Name | 3-[[2-chloro-4-(trifluoromethyl)phenoxy]methyl]-2-fluorobenzoic acid |
| InChI | InChI=1S/C15H9ClF4O3/c16-11-6-9(15(18,19)20)4-5-12(11)23-7-8-2-1-3-10(13(8)17)14(21)22/h1-6H,7H2,(H,21,22) |
| InChIKey | TWOXPNAILYKJPT-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)C(=O)O)F)COC2=C(C=C(C=C2)C(F)(F)F)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
