For research use only. Not for therapeutic Use.
MRL-871（Cat No.:I032776）is a selective positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R), a key target in the regulation of glucose metabolism and insulin secretion. Unlike traditional agonists, MRL-871 enhances the receptor’s response to endogenous GLP-1 without directly activating it, offering a more physiologically balanced approach to receptor modulation. This mechanism supports improved glucose control with potentially fewer side effects, making MRL-871 a promising candidate for type 2 diabetes and metabolic disorder treatment. It also serves as a valuable tool for studying GLP-1R signaling and allosteric modulation in metabolic research.
| CAS Number | 1392809-08-3 |
| Synonyms | 4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]indazol-3-yl]benzoic acid |
| Molecular Formula | C22H12ClF3N2O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]indazol-3-yl]benzoic acid |
| InChI | InChI=1S/C22H12ClF3N2O3/c23-16-6-3-5-15(22(24,25)26)18(16)20(29)28-17-7-2-1-4-14(17)19(27-28)12-8-10-13(11-9-12)21(30)31/h1-11H,(H,30,31) |
| InChIKey | DANLZOIRUUHIIX-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=NN2C(=O)C3=C(C=CC=C3Cl)C(F)(F)F)C4=CC=C(C=C4)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
