MRS 2578

• CAT Number: I004658
• CAS Number: 711019-86-2
• Molecular Formula: C20H20N6S4
• Molecular Weight: 472.70
• Purity: ≥95%
• Synonyms: 1-(3-isothiocyanatophenyl)-3-[4-[(3-isothiocyanatophenyl)carbamothioylamino]butyl]thiourea
• Target: P2Y Receptor
• Solubility: DMSO: ≥ 80 mg/mL
• Storage: 2-8°C
• IC50: 37 nM [1]
• InChI: InChI=1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)
• InChIKey: QOHNRGHTJPFMSL-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)N=C=S)NC(=S)NCCCCNC(=S)NC2=CC(=CC=C2)N=C=S

MRS 2578（Cat No.:I004658）is a highly potent inhibitor of the P2Y6 receptor, with an IC50 value of 37 nM. While it exhibits weak activity at the P2Y1, P2Y2, P2Y4, and P2Y11 receptors, its primary selectivity lies in targeting the P2Y6 receptor. P2Y6 receptors are involved in various physiological processes, including inflammation and immune responses. By inhibiting P2Y6 receptor signaling, MRS 2578 provides a valuable tool for studying the specific functions and potential therapeutic interventions associated with P2Y6 receptor activation in various disease conditions.

Reference

[1]. Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770.
[2]. Riegel AK, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood, 2011, 117(8), 2548-2555.
[3]. Vieira RP, et al. Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med, 2011, 184(2), 215-223.