For research use only. Not for therapeutic Use.
MRS2279 diammonium（Cat No.:I042681）is a selective and high-affinity antagonist of the P2Y1 receptor, exhibiting a Ki value of 2.5 nM and an IC₅₀ of 51.6 nM. It competitively inhibits ADP-induced platelet aggregation with a pKb of 8.05. The compound has been utilized in research to study the role of P2Y1 receptors in various physiological and pathological processes, including thrombosis and inflammation. For instance, MRS2279 has been shown to attenuate mechanical ventilation-induced lung and brain injuries by inhibiting ATP production and dopamine release. Proper handling and storage are essential to maintain its stability and reactivity.
| CAS Number | 2387505-47-5 |
| Synonyms | azane;[(1R,2S,4S,5S)-4-[2-chloro-6-(methylamino)purin-9-yl]-2-phosphonooxy-1-bicyclo[3.1.0]hexanyl]methyl dihydrogen phosphate |
| Molecular Formula | C13H24ClN7O8P2 |
| Purity | ≥95% |
| IUPAC Name | azane;[(1R,2S,4S,5S)-4-[2-chloro-6-(methylamino)purin-9-yl]-2-phosphonooxy-1-bicyclo[3.1.0]hexanyl]methyl dihydrogen phosphate |
| InChI | InChI=1S/C13H18ClN5O8P2.2H3N/c1-15-10-9-11(18-12(14)17-10)19(5-16-9)7-2-8(27-29(23,24)25)13(3-6(7)13)4-26-28(20,21)22;;/h5-8H,2-4H2,1H3,(H,15,17,18)(H2,20,21,22)(H2,23,24,25);2*1H3/t6-,7+,8+,13+;;/m1../s1 |
| InChIKey | MLPKPDFUVMQAOX-KOVKCLEESA-N |
| SMILES | CNC1=C2C(=NC(=N1)Cl)N(C=N2)[C@H]3C[C@@H]([C@]4([C@@H]3C4)COP(=O)(O)O)OP(=O)(O)O.N.N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
