For research use only. Not for therapeutic Use.
Smoothened (Smo) receptor antagonist (IC<sub>50</sub> = 0.5 <span class=/’symbol/’>μ</span>M in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC<sub>50</sub> = 2.5 <span class=/’symbol/’>μ</span>M); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC<sub>50</sub> = 2.5 <span class=/’symbol/’>μ</span>M in HEK293 cells).
| Catalog Number | I010986 |
| CAS Number | 330829-30-6 |
| Synonyms | N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide |
| Molecular Formula | C24H23N3O5S |
| Purity | ≥95% |
| Target | Smo |
| Solubility | Soluble to 100 mM in DMSO |
| Storage | Store at +4C |
| IUPAC Name | N-[(3-benzamidophenyl)carbamothioyl]-3,4,5-trimethoxybenzamide |
| InChI | InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33) |
| InChIKey | KVQVEZQDNHMQJV-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)C(=O)NC(=S)NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3 |
