MRT00033659

• CAT Number: I016664
• CAS Number: 1401731-54-1
• Molecular Formula: C₁₅H₁₄N₄O
• Molecular Weight: 266.30
• Purity: ≥95%
• IUPAC Name: N-[3-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)phenyl]acetamide
• InChI: InChI=1S/C15H14N4O/c1-9-14-7-12(8-16-15(14)19-18-9)11-4-3-5-13(6-11)17-10(2)20/h3-8H,1-2H3,(H,17,20)(H,16,18,19)
• InChIKey: YFBPGSDPFRCNOY-UHFFFAOYSA-N
• SMILES: CC1=C2C=C(C=NC2=NN1)C3=CC(=CC=C3)NC(=O)C

MRT00033659（Cat No.:I016664）is a selective inhibitor of the E3 ubiquitin ligase HUWE1, an enzyme involved in protein degradation and regulation of cellular processes such as DNA repair and apoptosis. By inhibiting HUWE1, MRT00033659 disrupts ubiquitination, leading to the stabilization of target proteins like p53, which plays a critical role in tumor suppression. This compound is of significant interest in cancer research, as it allows for the study of protein homeostasis and the development of novel therapeutic strategies targeting protein degradation pathways. MRT00033659 is valuable for advancing cancer and biochemical research.

Reference

[1]. Huart AS, et al. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novelactivator of the p53 pathway. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5578-85.