For research use only. Not for therapeutic Use.
MRT199665 (Cat No.:I017418) is a small molecule inhibitor that targets the WDR5-MLL interaction, which is essential for the activity of the MLL family of histone methyltransferases. By inhibiting this interaction, MRT199665 prevents the methylation of histone H3 lysine 4 (H3K4) and the expression of genes that promote cancer cell proliferation and survival. Preclinical studies have shown that MRT199665 has potent antitumor activity in leukemia and solid tumor models.
| Catalog Number | I017418 |
| CAS Number | 1456858-57-3 |
| Molecular Formula | C₂₈H₃₁N₅O₂ |
| Purity | ≥95% |
| Target | PI3K/Akt/mTOR |
| IUPAC Name | 7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-[3-(pyrrolidin-1-ylmethyl)anilino]pyrrolo[2,3-d]pyrimidin-6-one |
| InChI | InChI=1S/C28H31N5O2/c1-28(2)22-16-29-27(30-19-8-5-7-18(15-19)17-32-13-3-4-14-32)31-25(22)33(26(28)35)23-12-11-21-20(23)9-6-10-24(21)34/h5-10,15-16,23,34H,3-4,11-14,17H2,1-2H3,(H,29,30,31)/t23-/m0/s1 |
| InChIKey | OFIFLUFVENTCNZ-QHCPKHFHSA-N |
| SMILES | CC1(C2=CN=C(N=C2N(C1=O)C3CCC4=C3C=CC=C4O)NC5=CC=CC(=C5)CN6CCCC6)C |
