For research use only. Not for therapeutic Use.
MRT67307 HCl(CAT: I008197) is a potent ULK inhibitor and SIK inhibitor. MRT67307 potently inhibits ULK1 and ULK2 in vitro and blocks autophagy in cells. ULK1 inhibition results in the accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.
| Catalog Number | I008197 |
| CAS Number | 2080306-21-2 |
| Synonyms | MRT67307; MRT-67307; MRT 67307; MRT67307 HCl. MRT67307 hydrochloride;N-(3-((2-cyclopropyl-5-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)phenyl)amino)propyl)cyclobutanecarboxamide dihydrochloride |
| Molecular Formula | C27H38Cl2N4O |
| Purity | ≥95% |
| Target | ULK |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| Related CAS | 1190379-70-4 (HCl) |
| IUPAC Name | N-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide;dihydrochloride |
| InChI | InChI=1S/C27H36N4O.2ClH/c1-31-15-12-21-16-23(9-8-22(21)18-31)30-24-10-11-25(19-6-7-19)26(17-24)28-13-3-14-29-27(32)20-4-2-5-20;;/h8-11,16-17,19-20,28,30H,2-7,12-15,18H2,1H3,(H,29,32);2*1H |
| InChIKey | AVTUJIVDDXSHKB-UHFFFAOYSA-N |
| SMILES | O=C(C1CCC1)NCCCNC2=CC(NC3=CC4=C(CN(C)CC4)C=C3)=CC=C2C5CC5.[H]Cl.[H]Cl |
