For research use only. Not for therapeutic Use.
MRT67307 hydrochloride (Cat No.: I015522) is a potent and selective inhibitor of IKKε and TBK1, key kinases involved in inflammatory and immune signaling pathways. It effectively suppresses interferon regulatory factor (IRF) activation and cytokine production, making it a valuable tool for studying innate immunity, inflammation, and autoimmune diseases. MRT67307 also inhibits AMPK-related kinases, expanding its applications to metabolic research. Its high specificity and bioavailability ensure reliable results in exploring therapeutic strategies for conditions such as inflammatory disorders, viral infections, and metabolic syndromes.
| CAS Number | 2095432-39-4 |
| Molecular Formula | C₂₆H₃₇ClN₆O₂ |
| Purity | ≥95% |
| Target | Autophagy |
| IUPAC Name | N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide |
| InChI | 1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31) |
| InChIKey | UKBGBACORPRCGG-UHFFFAOYSA-N |
| SMILES | C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5 |
| Reference | [1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.<br>[2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.<br>[3]. Zhu Z, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. 26.37Cancer Discov. 2014 Apr;4(4):452-65. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
