MRT68921 hydrochloride

• CAT Number: I005769
• CAS Number: 2070014-87-6
• Molecular Formula: C25H35ClN6O
• Molecular Weight: 471.04
• Purity: ≥95%
• Target: ULK
• Solubility: H2O: ＞ 31mg/mL
• Storage: Store at -20°C
• IC50: 2.9/1.1 nM (ULK1/2)
• IUPAC Name: N-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide;hydrochloride
• InChI: InChI=1S/C25H34N6O.ClH/c1-31-13-10-19-14-21(9-8-20(19)16-31)29-25-28-15-22(17-6-7-17)23(30-25)26-11-3-12-27-24(32)18-4-2-5-18;/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H,27,32)(H2,26,28,29,30);1H
• InChIKey: SCEOGAWLKSVXHH-UHFFFAOYSA-N
• SMILES: CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5.Cl

MRT68921 Hydrochloride(CAT: I005769) is a highly potent and selective inhibitor of ULK1 and ULK2, key kinases involved in autophagy regulation. It exhibits an IC50 of 2.9 nM for ULK1 and achieves over a 30-fold reduction in IC50 for ULK2 compared to other inhibitors. By targeting these kinases, MRT68921 Hydrochloride disrupts autophagy initiation, making it an invaluable tool for studying autophagic processes and their implications in cellular homeostasis, cancer, and neurodegenerative diseases. Its exceptional potency and selectivity provide a robust platform for advancing research into ULK-mediated pathways and therapeutic applications.