For research use only. Not for therapeutic Use.
MRTX1133 (Cat No.: I038808) is a highly selective KRAS G12D inhibitor developed for targeted cancer therapy. It binds directly to the KRAS G12D mutant, a common oncogenic driver in pancreatic, colorectal, and lung cancers, preventing its activation and downstream signaling. Unlike previous KRAS inhibitors targeting G12C, MRTX1133 is designed specifically for G12D mutations, offering a promising treatment option for patients with limited targeted therapies. Preclinical studies have shown potent antitumor activity, making it a key candidate for precision oncology drug development.
| CAS Number | 2621928-55-8 |
| Molecular Formula | C33H31F3N6O2 |
| Purity | 95% |
| Documentation | |
| Target | MAPK/ERK Pathway |
| Appearance | Powder |
| IUPAC Name | 4-[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol |
| InChI | 1S/C33H31F3N6O2/c1-2-23-26(35)7-4-18-10-22(43)11-24(27(18)23)29-28(36)30-25(13-37-29)31(41-15-20-5-6-21(16-41)38-20)40-32(39-30)44-17-33-8-3-9-42(33)14-19(34)12-33/h1,4,7,10-11,13,19-21,38,43H,3,5-6,8-9,12,14-17H2/t19-,20?,21?,33+/m1/s1 |
| InChIKey | SCLLZBIBSFTLIN-IFMUVJFISA-N |
| SMILES | C#CC1=C(C=CC2=CC(=CC(=C21)C3=NC=C4C(=C3F)N=C(N=C4N5CC6CCC(C5)N6)OC[C@@]78CCCN7C[C@@H](C8)F)O)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
