For research use only. Not for therapeutic Use.
MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.
MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM[1].
MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid[1].
| Catalog Number | I013610 |
| CAS Number | 202808-11-5 |
| Synonyms | 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one |
| Molecular Formula | C11H6BrN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H6BrN3O3/c12-6-1-2-8-5(3-6)4-7-9(15(8)18)11(17)14-13-10(7)16/h1-4,17-18H |
| InChIKey | AXFGZZXFEDISAJ-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1Br)C=C3C(=C(N=NC3=O)O)N2O |
| Reference | [1]. Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 126 |
