For research use only. Not for therapeutic Use.
Ms-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016002 |
| CAS Number | 1312309-62-8 |
| Synonyms | tert-butyl 3-[2-(2-methylsulfonyloxyethoxy)ethoxy]propanoate |
| Molecular Formula | C12H24O7S |
| Purity | ≥95% |
| InChI | InChI=1S/C12H24O7S/c1-12(2,3)19-11(13)5-6-16-7-8-17-9-10-18-20(4,14)15/h5-10H2,1-4H3 |
| InChIKey | SXMMBKJCRVIEEX-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCOS(=O)(=O)C |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
