Ms-PEG4-MS

• CAT Number: R002330
• CAS Number: 55400-73-2
• Molecular Formula: C10H22O9S2
• Molecular Weight: 350.41
• Purity: ≥95%
• Synonyms: 2-[2-[2-(2-methylsulfonyloxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
• InChI: InChI=1S/C10H22O9S2/c1-20(11,12)18-9-7-16-5-3-15-4-6-17-8-10-19-21(2,13)14/h3-10H2,1-2H3
• InChIKey: GKMDADHKHXRPPF-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OCCOCCOCCOCCOS(=O)(=O)C

Ms-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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