MS-PEG4-THP

• CAT Number: I044727
• CAS Number: 145927-73-7
• Molecular Formula: C14H28O8S
• Molecular Weight: 356.43
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethyl methanesulfonate
• InChI: InChI=1S/C14H28O8S/c1-23(15,16)22-13-11-19-9-7-17-6-8-18-10-12-21-14-4-2-3-5-20-14/h14H,2-13H2,1H3
• InChIKey: IHVHEXYPQZJGKH-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OCCOCCOCCOCCOC1CCCCO1

MS-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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