MS023

• CAT Number: I002371
• CAS Number: 1831110-54-3
• Molecular Formula: C17H25N3O
• Molecular Weight: 287.4
• Purity: ≥95%
• Synonyms: N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine
• Target: Histone Methyltransferase
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• IC50: 4-119 nM
• InChI: InChI=1S/C17H25N3O/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3
• InChIKey: FMTVWAGUJRUAKE-UHFFFAOYSA-N
• SMILES: CC(C)OC1=CC=C(C2=CNC=C2CN(C)CCN)C=C1

MS023(CAT: I002371), with the chemical name (S)-N-(5-(2-(4-(1-(R)-ethylpyrrolidine-2-carboxamido)anilino)-4-methylthiazol-5-yl)thiazol-2-yl)pyridine-3-carboxamide, is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs). It exerts its inhibitory action by effectively targeting and binding to the active sites of type I PRMTs. With an IC50 range of 4-119 nM, MS023 demonstrates strong inhibitory effects against these enzymes, thereby potentially impacting various cellular processes that involve protein arginine methylation.

Reference

[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.