MS049

• CAT Number: I001859
• CAS Number: 1502816-23-0
• Molecular Formula: C15H24N2O
• Molecular Weight: 248.36
• Purity: ≥95%
• Target: Histone Methyltransferase
• Solubility: DMSO ≥ 31 mg/mL
• Storage: Store at -20°C
• IUPAC Name: N-methyl-2-(4-phenylmethoxypiperidin-1-yl)ethanamine
• InChI: InChI=1S/C15H24N2O/c1-16-9-12-17-10-7-15(8-11-17)18-13-14-5-3-2-4-6-14/h2-6,15-16H,7-13H2,1H3
• InChIKey: HBOJWAYLSJLULG-UHFFFAOYSA-N
• SMILES: CNCCN1CCC(CC1)OCC2=CC=CC=C2

MS049（Cat No.:I001859）is a selective inhibitor of the histone methyltransferase G9a, which plays a critical role in the regulation of gene expression by methylating histone H3 at lysine 9 (H3K9me1/2). By inhibiting G9a, MS049 alters the epigenetic landscape, leading to the reactivation of silenced tumor suppressor genes and potential anti-cancer effects. This compound has shown promise in preclinical studies, particularly in hematological malignancies and solid tumors where G9a is overexpressed. MS049’s unique mechanism of action provides valuable insights into the therapeutic potential of targeting histone methylation in cancer treatment.

Reference

[1]. Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15.