MS15 TFA

• CAT Number: I040825
• Molecular Formula: C66H80F3N11O7S
• Molecular Weight: 1228.47
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[11-[3-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-aminopyridin-3-yl)imidazo[4,5-b]pyridin-5-yl]phenyl]propanoylamino]undecanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C64H79N11O5S.C2HF3O2/c1-41(44-22-24-45(25-23-44)56-42(2)69-40-81-56)70-61(79)53-38-49(76)39-74(53)62(80)57(63(3,4)5)73-55(78)20-12-10-8-6-7-9-11-13-35-67-54(77)32-21-43-17-14-18-46(37-43)51-30-31-52-60(71-51)75(59(72-52)50-19-15-36-68-58(50)65)48-28-26-47(27-29-48)64(66)33-16-34-64;3-2(4,5)1(6)7/h14-15,17-19,22-31,36-37,40-41,49,53,57,76H,6-13,16,20-21,32-35,38-39,66H2,1-5H3,(H2,65,68)(H,67,77)(H,70,79)(H,73,78);(H,6,7)/t41-,49+,53-,57+;/m0./s1
• InChIKey: BUALJYDLGDPEOM-VMWZINGLSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCCCCCCNC(=O)CCC4=CC(=CC=C4)C5=NC6=C(C=C5)N=C(N6C7=CC=C(C=C7)C8(CCC8)N)C9=C(N=CC=C9)N)O.C(=O)(C(F)(F)F)O

​MS15 TFA(CAT: I040825) is a potent and selective PROTAC (Proteolysis Targeting Chimera) degrader of AKT isoforms, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively. In vitro studies have demonstrated that MS15 TFA significantly promotes the degradation of AKT in SW620 cells and MS21 cells harboring KRAS/BRAF resistance mutations. Additionally, MS15 TFA effectively inhibits the proliferation of KRAS mutant SW620 cells. In vivo, a single intraperitoneal administration of MS15 at 75 mg/kg in mice has shown bioavailability. These properties make MS15 TFA a valuable tool for research into AKT-related signaling pathways and potential therapeutic strategies targeting AKT-driven malignancies.