For research use only. Not for therapeutic Use.
MS417（Cat No.:I008209）is a selective inhibitor of the protein kinase IKKβ (IκB kinase β), a key regulator of the NF-κB signaling pathway, which is involved in inflammation and cancer progression. By targeting IKKβ, MS417 disrupts NF-κB activation, leading to reduced inflammatory responses and potential anti-tumor effects. This compound has shown efficacy in preclinical studies, particularly in cancers characterized by elevated NF-κB activity. MS417’s ability to modulate inflammatory pathways positions it as a promising candidate for therapeutic development, especially in treating inflammatory diseases and cancers driven by aberrant NF-κB signaling.
| Catalog Number | I008209 |
| CAS Number | 916489-36-6 |
| Synonyms | MS417; MS-417; MS 417; GTPL7512; GTPL-7512; GTPL 7512.;methyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
| Molecular Formula | C20H19ClN4O2S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | methyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate |
| InChI | InChI=1S/C20H19ClN4O2S/c1-10-11(2)28-20-17(10)18(13-5-7-14(21)8-6-13)22-15(9-16(26)27-4)19-24-23-12(3)25(19)20/h5-8,15H,9H2,1-4H3/t15-/m0/s1 |
| InChIKey | GGRCIHACOIMRKY-HNNXBMFYSA-N |
| SMILES | CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC)C4=CC=C(C=C4)Cl)C |
| Reference | </br> 1:Hu Y, Zhou J, Ye F, Xiong H, Peng L, Zheng Z, Xu F, Cui M, Wei C, Wang X, Wang Z, Zhu H, Lee P, Zhou M, Jiang B, Zhang DY. BRD4 inhibitor inhibits colorectal cancer growth and metastasis. Int J Mol Sci. 2015 Jan 16;16(1):1928-48. doi: 10.3390/ijms16011928. PubMed PMID: 25603177; PubMed Central PMCID: PMC4307342.</br> 2: Liu R, Zhong Y, Li X, Chen H, Jim B, Zhou MM, Chuang PY, He JC. Role of transcription factor acetylation in diabetic kidney disease. Diabetes. 2014 Jul;63(7):2440-53. doi: 10.2337/db13-1810. Epub 2014 Mar 7. PubMed PMID: 24608443; PubMed Central PMCID: PMC4066331. |
