MS4322 (isomer)

• CAT Number: I042764
• CAS Number: 2601727-80-2
• Molecular Formula: C55H76N10O12S
• Molecular Weight: 1101.32
• Purity: ≥95%
• Synonyms: N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-[[1-[2-[2-[2-[2-[2-[2-[[(2R)-1-[(2S,4R)-4-hydroxy-2-[[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]azetidin-3-yl]amino]pyrimidine-4-carboxamide
• InChI: InChI=1S/C55H76N10O12S/c1-36(38-10-12-40(13-11-38)50-37(2)59-35-78-50)60-53(71)46-24-43(66)31-65(46)54(72)51(55(3,4)5)62-48(68)32-76-22-20-74-18-16-73-17-19-75-21-23-77-33-49(69)64-28-42(29-64)61-47-25-45(57-34-58-47)52(70)56-26-44(67)30-63-15-14-39-8-6-7-9-41(39)27-63/h6-13,25,34-36,42-44,46,51,66-67H,14-24,26-33H2,1-5H3,(H,56,70)(H,60,71)(H,62,68)(H,57,58,61)/t36-,43-,44+,46+,51+/m1/s1
• InChIKey: XUJMNOQMXWVXQE-FKZVQDAVSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](C(C)(C)C)NC(=O)COCCOCCOCCOCCOCC(=O)N4CC(C4)NC5=NC=NC(=C5)C(=O)NC[C@@H](CN6CCC7=CC=CC=C7C6)O)O

MS4322 (isomer)（Cat No.:I042764）, also known as YS43-22 (isomer), is an isomeric form of MS4322—a potent and selective degrader of protein arginine methyltransferase 5 (PRMT5). PRMT5 plays a crucial role in various cellular processes, including gene expression and signal transduction. By promoting the degradation of PRMT5, MS4322 (isomer) effectively reduces PRMT5 protein levels in cells, leading to the inhibition of growth across multiple cancer cell lines. This compound serves as a valuable chemical tool for exploring PRMT5 functions in both health and disease contexts. It is commercially available for research purposes, with suppliers offering it in quantities ranging from milligrams to grams.