MS9427 TFA

• CAT Number: I041420
• Molecular Formula: C50H59ClF4N8O14
• Molecular Weight: 1107.50
• Purity: ≥95%
• Synonyms: 5-[2-[2-[2-[2-[2-[3-[4-[3-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypropyl]piperazin-1-yl]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C48H58ClFN8O12.C2HF3O2/c1-64-41-30-39-36(45(53-31-52-39)54-33-4-6-38(50)37(49)28-33)29-42(41)70-16-2-11-56-12-14-57(15-13-56)44(60)9-17-65-19-21-67-23-25-69-26-24-68-22-20-66-18-10-51-32-3-5-34-35(27-32)48(63)58(47(34)62)40-7-8-43(59)55-46(40)61;3-2(4,5)1(6)7/h3-6,27-31,40,51H,2,7-26H2,1H3,(H,52,53,54)(H,55,59,61);(H,6,7)
• InChIKey: SZDKGDPFHUTOHP-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCN(CC4)C(=O)CCOCCOCCOCCOCCOCCNC5=CC6=C(C=C5)C(=O)N(C6=O)C7CCC(=O)NC7=O.C(=O)(C(F)(F)F)O

MS9427 TFA（Cat No.:I041420）is a highly selective and potent inhibitor of the protein methyltransferase SETD7, an enzyme that catalyzes the methylation of lysine residues on histones and other substrates, playing a crucial role in regulating gene expression and cellular functions. By targeting SETD7, MS9427 TFA has shown potential in disrupting the epigenetic regulation of cancer cells, especially in hematologic malignancies and solid tumors. Its ability to modulate gene expression and influence cellular pathways like proliferation and apoptosis positions it as a promising therapeutic candidate in cancer treatment and other diseases involving epigenetic dysregulation.