MSA-2

• CAT Number: I032827
• CAS Number: 129425-81-6
• Molecular Formula: C14H14O5S
• Molecular Weight: 294.32
• Purity: 98%
• Synonyms: MSA 2; MSA2; MSA-2
• Target: STING
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: 4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
• InChI: InChI=1S/C14H14O5S/c1-18-10-5-8-6-13(9(15)3-4-14(16)17)20-12(8)7-11(10)19-2/h5-7H,3-4H2,1-2H3,(H,16,17)
• InChIKey: APCLRHPWFCQIMG-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C(S2)C(CCC(O)=O)=O)C=C1OC

MSA-2 (Cat.No:I032827) is a selective inhibitor of the mitotic kinase MPS1 (monopolar spindle 1), which plays a crucial role in regulating mitosis and ensuring proper chromosome alignment and segregation during cell division. Inhibition of MPS1 with MSA-2 disrupts the spindle assembly checkpoint, leading to mitotic errors and cell death, making it a potential candidate for cancer therapy. By targeting the mitotic checkpoint, MSA-2 shows promise in overcoming resistance to chemotherapy and enhancing cancer treatment efficacy.