For research use only. Not for therapeutic Use.
MSBN is a highly selective fluorogenic probe for thiols. MSBN can be used to image thiols in live cells selectively and specifically label protein thiols with a signal to determine various reversible protein thiol modifications[1].
MSBN (5 µM; 0-60 min) shows a clean reaction with thiols (1 mM) to give a remarkable fluorescence signal[1].
| Catalog Number | I032828 |
| CAS Number | 135980-66-4 |
| Synonyms | 2-butyl-6-methylsulfonylbenzo[de]isoquinoline-1,3-dione |
| Molecular Formula | C17H17NO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H17NO4S/c1-3-4-10-18-16(19)12-7-5-6-11-14(23(2,21)22)9-8-13(15(11)12)17(18)20/h5-9H,3-4,10H2,1-2H3 |
| InChIKey | XJWPRGLACNOMLF-UHFFFAOYSA-N |
| SMILES | CCCCN1C(=O)C2=C3C(=C(C=C2)S(=O)(=O)C)C=CC=C3C1=O |
| Reference | [1]. Zhou P, et al. Naphthalimide Scaffold Provides Versatile Platform for Selective Thiol Sensing and Protein Labeling. ACS Chem Biol. 2016 Apr 15;11(4):1098-105. |
