MSC-1186

• CAT Number: I042366
• CAS Number: 2871698-23-4
• Molecular Formula: C19H17ClFN7O2S
• Molecular Weight: 461.90
• Purity: ≥95%
• Synonyms: N-[3-[[[2-(5-chloro-4-fluoro-1H-benzimidazol-2-yl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]-N-methylmethanesulfonamide
• InChI: InChI=1S/C19H17ClFN7O2S/c1-28(31(2,29)30)19-11(4-3-8-23-19)10-24-14-7-9-22-17(26-14)18-25-13-6-5-12(20)15(21)16(13)27-18/h3-9H,10H2,1-2H3,(H,25,27)(H,22,24,26)
• InChIKey: WBFJDKLBAAHKIL-UHFFFAOYSA-N
• SMILES: CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2)C3=NC4=C(N3)C=CC(=C4F)Cl)S(=O)(=O)C

MSC-1186 is a highly selective pan-SRPK inhibitor. MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC50 values of 2.7 nM, 81 nM and 0.6 nM, respectively. MSC-1186 can be used for the research of cancer[1].
MSC-1186 has activity for SRPK1 and SRPK3 in HEK293T cells with EC50 values of 98 nM and 40 nM, respectively[1].
MSC-1186 has activity for SRPK1, SRPK2 and SRPK3 with IC50 values of 2.7 nM, 81 nM and 0.6 nM, respectively[1].
MSC-1186 has excellent kinome-wide selectivity[1].
MSC-1186 shows additive attenuation of SR-protein phosphorylation when is used in combination with CDC2-like kinase (CLK) inhibitors[1].

Reference

[1]. Martin Schröder, et al. MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. J Med Chem. 2022 Dec 14.
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