MSC-4106

• CAT Number: I043431
• CAS Number: 2738542-58-8
• Molecular Formula: C18H12F3N3O2
• Molecular Weight: 359.30
• Purity: ≥95%
• Synonyms: 2-methyl-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxylic acid
• InChI: InChI=1S/C18H12F3N3O2/c1-23-9-14-13-8-10(17(25)26)2-7-15(13)24(16(14)22-23)12-5-3-11(4-6-12)18(19,20)21/h2-9H,1H3,(H,25,26)
• InChIKey: HUSMWXZHQVTDRU-UHFFFAOYSA-N
• SMILES: CN1C=C2C3=C(C=CC(=C3)C(=O)O)N(C2=N1)C4=CC=C(C=C4)C(F)(F)F

MSC-4106（Cat No.:I043431）is a selective small-molecule inhibitor targeting protein tyrosine phosphatase SHP2 (Src homology region 2-containing protein tyrosine phosphatase-2), a key regulator in the RAS/MAPK signaling pathway. SHP2 plays a crucial role in cell proliferation, differentiation, and survival, and its dysregulation is associated with various cancers and developmental disorders. By inhibiting SHP2, MSC-4106 blocks aberrant downstream signaling, offering potential for treating cancers driven by mutations in upstream receptors or RAS pathway components. MSC-4106 is also a valuable tool for exploring SHP2’s role in oncogenesis and immune regulation, supporting targeted cancer therapy development.