For research use only. Not for therapeutic Use.
Potent human MC<sub>1</sub> receptor antagonist (IC<sub>50</sub> = 17 nM). Also partial agonist at human MC<sub>3</sub> and MC<sub>5</sub> receptors (EC<sub>50</sub> values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells <em>in vitro</em>. Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. <span class=/’symbol/’>γ</span>MSH analog.
| Catalog Number | P000324 |
| CAS Number | 1416983-77-1 |
| Molecular Formula | C62H82N20O13S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble to 1 mg/ml in water |
| Storage | Store at -20C |
| IUPAC Name | (3S)-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[(3R,6S,9S,12S,15S)-12-benzyl-9-[3-(diaminomethylideneamino)propyl]-15-(1H-imidazol-5-ylmethyl)-6-(1H-indol-3-ylmethyl)-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexazacyclotricosane-3-carbonyl]amino]-4-oxobutanoic acid |
| InChI | InChI=1S/C62H82N20O13S/c63-49(83)31-73-53(88)43(24-35-12-3-1-4-13-35)78-54(89)41(18-9-21-69-61(64)65)77-59(94)47(28-52(86)87)81-60(95)48-33-96-23-11-20-50(84)72-32-51(85)75-46(27-38-30-68-34-74-38)58(93)79-44(25-36-14-5-2-6-15-36)56(91)76-42(19-10-22-70-62(66)67)55(90)80-45(57(92)82-48)26-37-29-71-40-17-8-7-16-39(37)40/h1-8,12-17,29-30,34,41-48,71H,9-11,18-28,31-33H2,(H2,63,83)(H,68,74)(H,72,84)(H,73,88)(H,75,85)(H,76,91)(H,77,94)(H,78,89)(H,79,93)(H,80,90)(H,81,95)(H,82,92)(H,86,87)(H4,64,65,69)(H4,66,67,70)/t41-,42-,43-,44-,45-,46-,47-,48-/m0/s1 |
| InChIKey | QJBNFEXQHBDMQM-VTWSTLNFSA-N |
| SMILES | C1CC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSC1)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=CC=C2)C(=O)NCC(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5)CC6=CN=CN6 |
