MSI-1436

• CAT Number: I002401
• CAS Number: 186139-09-3
• Molecular Formula: C37H72N4O5S
• Molecular Weight: 685.06
• Purity: ≥95%
• Synonyms: Trodusquemine
• Target: Phosphatase
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 1 μM
• IUPAC Name: [(3R,6R)-6-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-[3-[4-(3-aminopropylamino)butylamino]propylamino]-7-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] hydrogen sulfate
• InChI: InChI=1S/C37H72N4O5S/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38/h26-35,39-42H,6-25,38H2,1-5H3,(H,43,44,45)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-/m1/s1
• InChIKey: WUJVPODXELZABP-FWJXURDUSA-N
• SMILES: CC(C)C(CCC(C)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)NCCCNCCCCNCCCN)C)O)C)OS(=O)(=O)O

MSI-1436 (Cat No.:I002401) is a naturally occurring aminosterol that inhibits protein tyrosine phosphatase 1B (PTP1B), a key regulator of insulin and leptin signaling. By inhibiting PTP1B, MSI-1436 enhances insulin sensitivity and promotes weight loss, making it a promising candidate for treating obesity and type 2 diabetes. Additionally, MSI-1436 has shown potential in cancer therapy by inhibiting tumor growth and metastasis. Its multifaceted therapeutic effects, including anti-inflammatory and cardioprotective properties, position MSI-1436 as a valuable compound for research in metabolic disorders and oncology.