MSI-2216

• CAT Number: I032835
• CAS Number: 469867-30-9
• Molecular Formula: C22H15F3N2O3
• Molecular Weight: 412.3682
• Purity: 98%
• Synonyms: MSI-2216; MSI 2216; MSI2216
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1(3H)-Isobenzofuranone, 3-(2-oxo-2-(2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinyl)ethyl)-
• InChI: InChI=1S/C22H15F3N2O3/c23-22(24,25)13-5-3-6-14(11-13)27-20-17(9-4-10-26-20)18(28)12-19-15-7-1-2-8-16(15)21(29)30-19/h1-11,19H,12H2,(H,26,27)
• InChIKey: FPUWITQFSOFORR-UHFFFAOYSA-N
• SMILES: O=C1OC(CC(C2=CC=CN=C2NC3=CC=CC(C(F)(F)F)=C3)=O)C4=C1C=CC=C4

MSI-2216 is a bioactive chemical.

Reference

1: Hauber HP, Daigneault P, Frenkiel S, Lavigne F, Hung HL, Levitt RC, Hamid Q. Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa. J Allergy Clin Immunol. 2005 Feb;115(2):266-71. doi: 10.1016/j.jaci.2004.09.039. PMID: 15696080.
2: Hauber HP, Goldmann T, Vollmer E, Wollenberg B, Hung HL, Levitt RC, Zabel P. LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors. J Endotoxin Res. 2007;13(2):109-16. doi: 10.1177/0968051907079168. PMID: 17621552.
3: Hauber HP, Steffen A, Goldmann T, Vollmer E, Hung HL, Wollenberg B, Zabel P. Effect of steroids, acetyl-cysteine and calcium-activated chloride channel inhibitors on allergic mucin expression in sinus mucosa. Laryngoscope. 2008 Sep;118(9):1528-33. doi: 10.1097/MLG.0b013e31817b0732. PMID: 18596559.