MSI-2216

• CAT Number: I032835
• CAS Number: 469867-30-9
• Molecular Formula: C22H15F3N2O3
• Molecular Weight: 412.37
• Purity: 98%
• Synonyms: MSI-2216; MSI 2216; MSI2216
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-[2-oxo-2-[2-[3-(trifluoromethyl)anilino]pyridin-3-yl]ethyl]-3H-2-benzofuran-1-one
• InChI: InChI=1S/C22H15F3N2O3/c23-22(24,25)13-5-3-6-14(11-13)27-20-17(9-4-10-26-20)18(28)12-19-15-7-1-2-8-16(15)21(29)30-19/h1-11,19H,12H2,(H,26,27)
• InChIKey: FPUWITQFSOFORR-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(OC2=O)CC(=O)C3=C(N=CC=C3)NC4=CC=CC(=C4)C(F)(F)F

MSI-2216(CAT: I032835) is a selective and potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme involved in the metabolism of tryptophan to kynurenine. By inhibiting IDO1, MSI-2216 reduces kynurenine production, restoring immune system activity and promoting an anti-tumor immune response. This mechanism makes it a valuable tool in cancer immunotherapy research, particularly for studying the role of tryptophan metabolism in tumor immune evasion. MSI-2216 has potential applications in exploring combination therapies targeting immune checkpoints, providing insights into novel strategies to enhance anti-tumor immunity in cancer treatment.