mTOR inhibitor-1

• CAT Number: I019335
• CAS Number: 468747-17-3
• Molecular Formula: C₁₆H₁₅BrN₂O₃
• Molecular Weight: 363.21
• Purity: ≥95%
• Target: mTOR; Autophagy
• Storage: Store at -20°C
• IUPAC Name: 3-bromo-N-[(E)-1-(2,4-dihydroxyphenyl)ethylideneamino]-4-methylbenzamide
• InChI: InChI=1S/C16H15BrN2O3/c1-9-3-4-11(7-14(9)17)16(22)19-18-10(2)13-6-5-12(20)8-15(13)21/h3-8,20-21H,1-2H3,(H,19,22)/b18-10+
• InChIKey: NKMSVTGHOVMMHV-VCHYOVAHSA-N
• SMILES: CC1=C(C=C(C=C1)C(=O)NN=C(C)C2=C(C=C(C=C2)O)O)Br

mTOR inhibitor-1（Cat No.:I019335） is an innovative inhibitor of the mTOR pathway, a key signaling pathway involved in cellular growth and proliferation. This compound effectively suppresses cell proliferation by targeting mTOR, thereby halting the excessive division of cells. Additionally, mTOR inhibitor-1 induces autophagy, a cellular process that promotes the recycling and elimination of damaged components, leading to cellular homeostasis. Through its dual mechanism of action, mTOR inhibitor-1 holds promise as a potential therapeutic agent for conditions characterized by abnormal cell growth and impaired autophagy.

Reference

[1]. Liu J, et al. In Silico Discovery of a Small Molecule Suppressing Lung Carcinoma A549 Cells Proliferation and Inducing Autophagy via mTOR Pathway Inhibition. Mol Pharm. 2018 Nov 5;15(11):5427-5436.