mTOR Inhibitor, Ku-0063794

• CAT Number: I005576
• CAS Number: 938440-64-3
• Molecular Formula: C₂₅H₃₁N₅O₄
• Molecular Weight: 465.54
• Purity: ≥95%
• Synonyms: KU0063794
• Target: mTOR
• Solubility: DMSO ≥10mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
• Storage: 3 years -20C powder
• IC50: ~10 nM
• IUPAC Name: [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• InChI: InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+
• InChIKey: RFSMUFRPPYDYRD-CALCHBBNSA-N
• SMILES: C[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5

Ku-0063794(CAT: I005576) is a potent, selective, and ATP-competitive inhibitor of mTOR (mammalian target of rapamycin), targeting both mTORC1 and mTORC2 complexes. It exhibits an IC50 of 10 nM for mTOR kinase activity and does not significantly inhibit related kinases, such as PI3K. Ku-0063794 is widely used in research to explore mTOR signaling pathways, which play a crucial role in cell growth, proliferation, metabolism, and autophagy. Its dual inhibition of mTORC1 and mTORC2 provides insights into mTOR-mediated cellular processes and aids in the development of therapies for cancer, neurodegenerative diseases, and metabolic disorders.