MTX-211

• CAT Number: I005983
• CAS Number: 1952236-05-3
• Molecular Formula: C₂₀H₁₄Cl₂FN₅O₂S
• Molecular Weight: 478.33
• Purity: ≥95%
• Synonyms: N-[2-chloro-5-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]pyridin-3-yl]methanesulfonamide
• Target: Protein Tyrosine Kinase/RTK
• Solubility: DMSO
• Storage: -20°C
• InChI: InChI=1S/C20H14Cl2FN5O2S/c1-31(29,30)28-18-7-12(9-24-19(18)22)11-2-5-17-14(6-11)20(26-10-25-17)27-13-3-4-16(23)15(21)8-13/h2-10,28H,1H3,(H,25,26,27)
• InChIKey: GUYKCXXNIKKSBC-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)NC1=C(N=CC(=C1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)Cl

MTX-211(CAT: I005983) is a dual inhibitor targeting EGFR and PI3K, making it a valuable tool in oncology research. This compound is particularly effective in studying signaling pathways associated with tumor growth, survival, and resistance mechanisms. By simultaneously inhibiting EGFR and PI3K, MTX-211 helps unravel the complexities of cancer progression and offers potential insights into novel combination therapies. With its high potency and specificity, it is ideal for preclinical studies exploring targeted treatments for various cancers, including those resistant to single-pathway inhibitors. MTX-211 is a critical asset for advancing cancer drug discovery and translational research.