MurA-IN-1

• CAT Number: I045239
• CAS Number: 354815-90-0
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.25
• Purity: ≥95%
• Synonyms: 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid
• InChI: InChI=1S/C13H13NO2/c15-13(16)12-10-6-3-5-8(10)9-4-1-2-7-11(9)14-12/h1-5,7-8,10,12,14H,6H2,(H,15,16)
• InChIKey: WRJCENKZISEXPF-UHFFFAOYSA-N
• SMILES: C1C=CC2C1C(NC3=CC=CC=C23)C(=O)O

MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively[1]. (A family of human MAPK-specific protein tyrosine phosphatases)

Reference

[1]. Jeyanthy Eswaran, et al. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem J. 2006 May 1;395(3):483-91.
 [Content Brief]