Muraglitazar

• CAT Number: I008215
• CAS Number: 331741-94-7
• Molecular Formula: C29H28N2O7
• Molecular Weight: 516.55
• Purity: ≥95%
• Synonyms: Pargluva
• Target: Vitamin D Related/Nuclear Receptor
• Solubility: Soluble in DMSO, not in water
• Storage: Store at 4°C
• IUPAC Name: 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid
• InChI: InChI=1S/C29H28N2O7/c1-20-26(30-28(37-20)22-6-4-3-5-7-22)16-17-36-24-10-8-21(9-11-24)18-31(19-27(32)33)29(34)38-25-14-12-23(35-2)13-15-25/h3-15H,16-19H2,1-2H3,(H,32,33)
• InChIKey: IRLWJILLXJGJTD-UHFFFAOYSA-N
• SMILES: CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=CC=C(C=C3)CN(CC(=O)O)C(=O)OC4=CC=C(C=C4)OC

Muraglitazar(CAT: I008215) is a dual PPARα/γ agonist that modulates peroxisome proliferator-activated receptor (PPAR) pathways, which are key regulators of lipid and glucose metabolism. By activating PPARα, Muraglitazar promotes lipid lowering, while its PPARγ activation enhances insulin sensitivity, making it a candidate for treating type 2 diabetes and related metabolic disorders. Despite its potential, concerns over cardiovascular side effects have limited its clinical use. Muraglitazar remains a valuable tool in metabolic research, particularly for studying PPAR-mediated pathways, lipid regulation, and insulin signaling, contributing to the development of safer and more effective therapies for metabolic diseases.