MuRF1-IN-1

• CAT Number: I017784
• CAS Number: 445222-91-3
• Molecular Formula: C₁₈H₁₅N₃O₃
• Molecular Weight: 321.33
• Purity: ≥95%
• IUPAC Name: 2-amino-1'-methyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile
• InChI: InChI=1S/C18H15N3O3/c1-21-12-6-3-2-5-10(12)18(17(21)23)11(9-19)16(20)24-14-8-4-7-13(22)15(14)18/h2-3,5-6H,4,7-8,20H2,1H3
• InChIKey: VXTHFLXWLSPJSP-UHFFFAOYSA-N
• SMILES: CN1C2=CC=CC=C2C3(C1=O)C(=C(OC4=C3C(=O)CCC4)N)C#N

MuRF1-IN-1(CAT: I017784) is a selective inhibitor of Muscle RING-Finger Protein-1 (MuRF1), a key E3 ubiquitin ligase involved in muscle protein degradation and atrophy. It is extensively used in research to study the regulation of muscle mass and the mechanisms underlying muscle wasting in conditions such as cachexia, sarcopenia, and muscular dystrophies. By targeting MuRF1, MuRF1-IN-1 helps to elucidate the pathways associated with ubiquitin-proteasome-mediated proteolysis and muscle homeostasis. Its specificity and effectiveness make it a critical tool for advancing therapeutic strategies aimed at preserving muscle mass in chronic diseases and aging.