Murideoxycholic Acid

• CAT Number: R066647
• CAS Number: 668-49-5
• Molecular Formula: C24H40O4
• Molecular Weight: 392.58
• Purity: 95%
• Synonyms: MDCA;Muricholic Acid;NSC 18166
• Target: Endogenous Metabolite
• Appearance: A crystalline solid
• Storage: -20°C
• IUPAC Name: 4-(3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
• InChI: InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)
• InChIKey: DGABKXLVXPYZII-UHFFFAOYSA-N
• SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CC(C4C3(CCC(C4)O)C)O)C

Murideoxycholic acid (MDCA) is a secondary bile acid produced from cholesterol by way of chenodeoxycholic acid , α-muricholic acid (Item No. 20291), and hyocholic acid. MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet., Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl taurine. In humans, MDCA is rapidly absorbed and is metabolized as an endogenous bile acid with a half-life of approximately 3.5 days.

Reference

1.Kuipers, F.,Bloks, V.W. and Groen, A.K. Beyond intestinal soap–bile acids in metabolic control. Nat. Rev. Endocrinol. 10(8), 488-498 (2014).